Blood brain barrier

Blood brain barrier
The Blood brain barrier profiler is associated with phenomena penetration of chemicals from blood to the brain. Modeled endpoint used in the current profiler is: LogBBB. The profiler consists of two categories: “Good permeable” and “Poor permeable”. The categories are based on parametric boundaries. The values for parametric boundaries ensure maximum specificity given the sensitivity threshold (sensitivity >= 80%; i.e. risk <= 20%). The profiler was developed on a basis of classification tree approach. The process of boundaries generation is oriented towards the hazard predictions of chemicals. The profiler was developed from a dataset of 1782 discrete chemicals with observed logBBB data. The profiler is appropriate for classification of chemicals and it is not recommended to be used for predictive purposes.

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