Oral absorption

The Oral absorption profiler is associated with administration of chemicals into the body and more specifically with “oral” administration. The profiler is relevant to following hazard endpoints: acute oral toxicity; repeated dose toxicity; developmental toxicity and others. Modeled endpoint used in current profiler is: Caco-2 Papp, cm/s (Papp). The profiler consists of three categories: “Highly absorbed; “Lowly absorbed” and “Moderately absorbed”, based on parametric boundaries only. The values for parametric boundaries ensure maximum specificity given the sensitivity threshold (sensitivity >= 80%; i.e. risk <= 20%). The profiler is oriented towards the hazard predictions. The parametric boundaries are derived based on a classification tree approach using a set of 1988 training set chemicals. The profiler is appropriate for classification of chemicals and it is not recommended to be used for predictive purposes.