Oral absorption

Oral absorption
The Oral absorption profiler is associated with administration of chemicals into the body and more specifically with “oral” administration. The profiler is relevant to following hazard endpoints: acute oral toxicity; repeated dose toxicity; developmental toxicity and others. Modeled endpoint used in current profiler is: Caco-2 Papp, cm/s (Papp). The profiler consists of three categories: “Highly absorbed; “Lowly absorbed” and “Moderately absorbed”, based on parametric boundaries only. The values for parametric boundaries ensure maximum specificity given the sensitivity threshold (sensitivity >= 80%; i.e. risk <= 20%). The profiler is oriented towards the hazard predictions. The parametric boundaries are derived based on a classification tree approach using a set of 1988 training set chemicals. The profiler is appropriate for classification of chemicals and it is not recommended to be used for predictive purposes.

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