Oral absorption

Oral absorption
Current version:
1.0.0.0
Developer:
LMC
Category:
Profilers
Downloads:
43
Rating:
0
Description:
The Oral absorption profiler is associated with administration of chemicals into the body and more specifically with “oral” administration. The profiler is relevant to following hazard endpoints: acute oral toxicity; repeated dose toxicity; developmental toxicity and others. Modeled endpoint used in current profiler is: Caco-2 Papp, cm/s (Papp). The profiler consists of three categories: “Highly absorbed; “Lowly absorbed” and “Moderately absorbed”, based on parametric boundaries only. The values for parametric boundaries ensure maximum specificity given the sensitivity threshold (sensitivity >= 80%; i.e. risk <= 20%). The profiler is oriented towards the hazard predictions. The parametric boundaries are derived based on a classification tree approach using a set of 1988 training set chemicals. The profiler is appropriate for classification of chemicals and it is not recommended to be used for predictive purposes.

The plug-in developer is responsible for the correct functioning of the plug-in and its results. Before being made available via the repository, the plug-ins are checked for viruses, impact on stability of the QSAR Toolbox and documentation. For suggestions on improvement or bug fixing of the plug-in, please contact its developer directly.


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