KATE Addin

KAshinhou Tool for Ecotoxicity (KATE) is an ecotoxicity prediction system that consists of quantitative structure–activity relationship (QSAR) models and was researched and developed under contract with the Ministry of the Environment, Government of Japan from fiscal year 2004 to 2019 by the Center for Health and Environmental Risk Research (CHERR) of the National Institute for Environmental Studies (NIES). KATE was originally developed to provide predicted ecotoxicity values—specifically, 50% effective concentration (EC50) values in the Daphnia acute immobilization test and 50% lethal concentration (LC50) values in the fish acute toxicity test—for chemical substances on the basis of their substructures. Since KATE2017, the predicted ecotoxicity values of the following endpoints are provided: EC50 and no-observed-effect concentration (NOEC) values in the algal growth inhibition test (72 h); NOEC values in the Daphnia magna reproduction test (21 d); and NOEC values in the fish early-life-stage toxicity test.